Five rookie quarterbacks will be making their NFL regular season debuts on Sunday.  Which rookie will throw for the most yards? The betting favorite is number one overall pick Andrew Luck of the Indianapolis Colts.  After that, it’s between the second overall pick, Robert Griffin III of the Washington Redskins, and third-round pick Russell Wilson of the Seattle Seahawks.

Two other first rounders, Miami’s Ryan Tannehill and Cleveland’s Brandon Weeden are also in the mix.

For what it’s worth, Wilson threw for the most yards of the five in the preseason.  RGIII takes over the team that averaged the most passing yards last season, while Luck’s Colts averaged the least passing yards last season.  RGIII and Luck both face teams that allowed a lot of passing yards last season, while Tannehill faces the defense that allowed the least passing yards last season.  Below, we have the odds as well as a complete breakdown of opponents, preseason stats and last year’s team stats.

Odds on which Rookie Quarterback will have the most passing yards in Week 1:

Andrew Luck, Colts @ Bears +175
Robert Griffin III, Redskins @ Saints +200
Russell Wilson, Seahawks @ Cardinals +200
Ryan Tannehill, Dolphins @ Texans +750
Brandon Weeden, Browns vs. Eagles +750

Preseason Stats:

Luck 41 completions/66 attempts for 522 yards
RGIII 20/31, 193 yds
Wilson 40/63, 536 yds
Weeden 24/49, 297 yds
Tannehill 41/78, 414

2011 Team Stats:

Colts Passing Yds/Game: 187.2
Bears Passing Yds Allowed/Game: 254.1

Redskins PYG: 235.8
Saints PYAG: 259.8

Seahawks PYG: 194.1
Cardinals PYAG: 231.0

Dolphins PYG: 193.2
Texans PYAG: 189.7

Browns PYG: 193.1
Eagles PYAG: 212.3